Ion Transport from Physics to Physiology: the Missing Rungs in the Ladder

April 3, 2017 to April 5, 2017
Location : CECAM-HQ-EPFL, Lausanne, Switzerland
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The molecular dynamics of potassium channel permeation, selectivity and gating

Bert de Groot
Max Planck Institute for Biophysical Chemistry, Göttingen, Germany


Ion channels facilitate the passive, selective permeation of ions such as sodium, potassium and chloride across biological membranes and as such are essential for cellular electrical signalling. Molecular dynamics simulations based on the computational electrophysiology scheme will be presented to study ion permeation across potassium channels. Together with crystallographic analyses analyses and electrophysiology experiments these provide insight into the mechanisms of permeation, selectivity and gating in potassium channels.