The Structural Genome: Merging Physics, Biology and Computation
International Center for Theoretical Physics (ICTP, Trieste, Italy)
The life of any single cell proceeds strictly from the information coded by the linear filament of DNA suitably folded inside a well-recognizable cellular structure, the nucleus in eukaryotes, and the nucleoid in prokaryotes. It is now well established, that the information coded by DNA is much more than the mere reflex of the polynucleotide sequence, but it is the result of the three-dimensional dynamic organization of DNA sequence in the space of the cell [1-3]. In particular, the determinants of folding also influence how genomes tend "to react" to external stimuli , or when the healthy behavior of the cell is harmed by internal and/or external factors which may cause the death of the cell or of the entire organism.
The structure/function relationship of genomes (from bacteria to higher eukaryotes including humans) is the focus of an intense multi-disciplinary effort, where experimental teams (super-resolution microscopy ,
chromosome conformation capture , in-vivo fluorescence imaging , ...) work side-by-side of theoretical ones (physical/mathematical models for the genomes [3,7,8], statistical analysis of gene expression profiles , bioinformatics analysis of DNA sequences , ...), with the mutual greatest benefit.
The main goal of the Workshop is precisely to present the current state-of-the-art in this exciting and interdisciplinary field by putting together some amongst the most internationally recognized scientists in the topic.
Angelo Rosa (Scuola Internazionale Superiore di Studi Avanzati (SISSA)) - Organiser
Thomas C Bishop (Louisiana Tech University) - Organiser
Catherine Musselman (University of Colorado Anschutz Medical Campus) - Organiser
Tamar Schlick (New York University) - Organiser
Jeff Wereszczynski (Illinois Institute of Technology) - Organiser