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Ion channels play a key role in the physiology of both excitable (e.g. neurons, muscle, heart) and non-excitable (e.g. pancreas, bacteria) cells. They provide pathways for fast (107 ions s-1) and controlled flow of selected ions. Channels may be gated, i.e. regulated, by a number of factors including e.g. lateral pressure, pH, transmembrane voltage and/or binding of ligands.The aim of the workshop is to bring together experimentalists and modelers in order to relate the progress made so far and to devise new synergies aimed at:
1. Understanding fundamental physical mechanisms of ion channel processes including permeation, selectivity and gating; and
2. Relating atomic resolution structures of ion channels to their physiological function.
Three main topics will be covered
Design principles and properties of model systems & nanotubes.
- Realistic transport modeling multiscale approaches vs. brute force MD?
- Conformational change gating (insights from both experimental and theoretical investigations)
France
United Kingdom
Ionic Transport: from Nanopores to Biological Channels
Location: CECAM 46 allée d'Italie 69007 Lyon France
Organisers
References
Mounir TAREK (CNRS - Uniersité de Lorraine) - Organiser
United Kingdom
Mark Sansom (University of Oxford) - Organiser